ADIKES LAB
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Research.

The long-term goal of our research is to understand how the actin cytoskeleton regulates cell migration and adhesion in an in vivo context. We use the power of C.elegans genetics and imaging to investigate the role of actin regulators during cell migration in vivo.  

Research

We use the sex myoblast cells of C.elegans to probe the role of the actin cytoskeleton in long distance cell migration. The sex myoblasts (SMs) migrate ~65 microns during the second larval stage to arrive at the center of the gonad where they then divide and differentiate into the uterine and vulval muscle cells (ums and vms). We have established protocols to image this migration and are currently working on quantification of membrane and actin dynamics. Preliminary data, that the lab will confirm and expand upon, shows that key actin regulators are required for this process.  Future research endeavors will address if this mechanism of actin based migration is conserved in the presomitic mesodermal cells of zebrafish.
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Check out what we worked  on last summer!

Collaborations

The Adikes lab is looking forward to collaborating with scientists who design and use advanced imaging techniques to visualize highly dynamic  cellular and sub-cellular events!

Mentoring

The Adikes lab fosters the growth and technical training of undergraduate scholars in a supportive and engaging environment! 

Publications

Mondal, C., Gacha-Garay, M.J., Adikes R.C., Larkin, K., Di Martino J, Chien C-C., Fraser, M., Eni-aganga, I., Agullo-Pascual, E., Ozbek,U., Naba, A.,  Gaitas, A., Fu, T-M., Upadhyayula, S., Betzig, E., Matus, D.Q., Martin, B.L., and Bravo-Cordero, J.J. (2022) A proliferative-to-invasive switch is mediated by srGAP1 downregulation through the activation of TGFβ2 signaling. Cell Reports.
 
Palmisano, N.J.#, Azmi, M.A.#, Medwig-Kinney, T.N., Moore, F.E.Q., Rahman R., Zhang, W, Adikes, R.C.%, Matus, D.Q.%. (2022). A laboratory module that explores RNA interference and codon optimization through fluorescence microscopy using Caenorhabditis elegans. CourseSource DOI:https://doi.org/10.24918/cs.2022.15
#these authors contributed equally, %co-corresponding


Morabito, R. D., Adikes, R. C., Matus, D. Q., Martin, B. L. (2021) Cyclin-Dependent Kinase Sensor Transgenic Zebrafish Lines for Improved Cell Cycle State Visualization in Live Animals. Zebrafish.
DOI: 10.1089/zeb.2021.0059


Smith, J.J., Xiao, Y., Medwig-Kinney, T.N.,  Martinez, M.A.Q., Moore, F.E.Q., Palmisano, N.J., Kohrman, A.Q., Chandok Delos Reyes, M., Adikes, R.C.,  Liu, S., Bracht, S.A., Zhang, W., Wen, K., Krastsios, P., Matus, D.Q. (2021) The SWI/SNF chromatin remodeling assemblies BAF and PBAF differentially regulate cell cycle exit and cellular invasion in vivo.  PLOS Genetics DOI:http://doi.org/10.1371/journal.pgen.1009981
 
Adikes, R.C.#, Kohrman, A.Q.#, Martinez, M.A.Q.#, Palmisano, N.J., Smith, J.J., Medwig-Kinney, T.N., Min M., Sallee, M.D., Ahmed, O.B.*^, Kim, N.^,  Liu, S., Morabito, R.D.,  Weeks, N.,  Zhao, Q., Zhang, W., Feldman, J.L., Barkoulas, M., Pani, A.M., Spencer S.L., Martin, B.L., and Matus, D.Q. (2020). Visualizing the metazoan proliferation-differentiation decision in vivo. eLife 9:e63265 DOI: 10.7554/eLife.63265 
#these authors contributed equally

Invited Talks

Adikes, R.C. (2022) How cells move and navigate complex environments. Bennington College Science Workshop, Bennington, VT
Adikes, R.C
. (2022) Matching Sample to System.
Light Sheet Fluorescence Microscopy Workshop. Marine Biological Laboratories, Woods Hole, MA
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Adikes, R.C. (2021) Membrane and cytoskeletal dynamics during muscle progenitor migration. ASCB Cell Bio Annual Meeting subgroup on Cytoskeletal dynamics in health and disease. Virtual
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Adikes, R.C. (2021) Regulation of cell migration during development and disease. Siena College Biology Department Seminar. Virtual

Poster Presentations

Razi, M., Fitian, M., Shezhad, S., McKnight, T. Ahmed O.B., Matus, D.Q.,  Gibney, T., Pani, A.P., Adikes, R.C. Roles of Cytoskeletal Genes in C.elegans Sex Myoblast Development. 2022 Siena Summer Research Symposium and 2022 ASCB Annual Meeting

Shezhad, S., McKnight, T., Adikes, R.C. Cell migration in C. elegans as a model for development and disease. 2022 Siena Academic Showcase
 
Adikes, R.C., Moore, F.E.Q, Fang, A., Martinez M.A.Q.M., Ahmed O.B., Medwig-Kinney T.N., Zhang W., Gibney, T., Pani, A.M., Stern, M.J., Matus, D.Q. Understanding the Quiescence to Proliferative Switch in vivo. 2021 ASCB Annual Meeting

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  • Home
  • Research
  • Meet the Team!
  • Contact
  • Lab Documents
    • Lab Code of Conduct
    • Safety Training
    • Information for Students
    • Strain, Plasmid and Antibody Storage